Conditioning for allogeneic marrow transplantation in patients with lymphohematopoietic malignancies without the use of total body irradiation
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چکیده
منابع مشابه
Conditioning for allogeneic marrow transplantation in patients with lymphohematopoietic malignancies without the use of total body irradiation.
VIDENCE THAT INFUSION of syngeneic spleen or E marrow cells could protect mice and guinea pigs from lethal doses of irradiation' led Thomas et a1 to perform studies on total body irradiation (TBI) and marrow transplantation in dogs and eventually in human^.^-^ TBI was chosen because irradiation could be delivered expeditiously, did not generate metabolites that might interfere with the function...
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Total-body irradiation (TBI), when given as part of bone marrow transplantation (BMT), works by enhancing immune suppression and by exerting a tumoricidal effect. The modality has been made less toxic because of new approaches to delivering TBI, such as fractionation, and partial organ shielding, Colleen Lawton, MD, professor at the Medical College of Wisconsin, Milwaukee, said at the 1998 Amer...
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Current therapies for acute myeloid leukemia (AML), failing induction, are rarely effective. We report our experience in 4 patients with AML who received 16 Gy TBI prior to allogeneic hematopoietic cell transplantation (alloHCT), between June 2010 and May 2011. Patients were 20 to 55 years of age, 2 with relapsed disease and 2 with AML failing induction. An HLA-matched graft from related or unr...
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Between October 1988 and December 1992, 167 patients with leukemia receiving marrow transplants from HLA-identical donors and conditioned with cyclophosphamide (120 mg/kg) were randomized to additional treatment with either busulfan (16 mg/kg, n = 88) or total body irradiation (TBI; n = 79). The busulfan-treated patients had an increased cumulative incidence of veno-occlusive disease of the liv...
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Introduction For the treatment of childhood leukemia and other oncologic disorders, total body irradiation (TBI) associated with high doses of chemotherapy had been included in some of the conditioning regimens given before an allogeneic bone marrow transplantation (BMT) 1). The increasing use of BMT in the treatment of malignant diseases in childhood has revealed several long-term sequelae suc...
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ژورنال
عنوان ژورنال: Blood
سال: 1992
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v80.7.1648.1648